Pickering-Type Water-in-Oil-in-Water Multiple Emulsions toward Multihollow Nanocomposite Microspheres
journal contributionposted on 07.09.2010, 00:00 by Hayata Maeda, Masahiro Okada, Syuji Fujii, Yoshinobu Nakamura, Tsutomu Furuzono
Multihollow hydroxyapatite (HAp)/poly(l-lactic acid) (PLLA) nanocomposite microspheres were readily fabricated by solvent evaporation from a “Pickering-type” water-in-(dichloromethane solution of PLLA)-in-water multiple emulsion stabilized with HAp nanoparticles. The multiple emulsion was stabilized with the aid of PLLA molecules used as a wettability modifier for HAp nanoparticles, although HAp nanoparticles did not work solely as particulate emulsifiers for Pickering-type emulsions consisting of pure dichloromethane and water. The interaction between PLLA and HAp nanoparticles at the oil−water interfaces plays a crucial role toward the preparation of stable multiple emulsion and multihollow microspheres.