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Phytotoxic ent-Isopimarane-Type Diterpenoids from Euphorbia hylonoma

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journal contribution
posted on 06.11.2018, 20:36 by Wen-Jun Wei, Qiu-Yan Song, Zai-Qin Zheng, Xiaojun Yao, Ya Li, Kun Gao
Thirteen new ent-isopimarane-type diterpenoids, 110 and 1416, and seven known diterpenoids, 1113 and 1720, were isolated from the roots of Euphorbia hylonoma. Among these compounds, four pairs of C-12 epimers (1 vs 2, 4 vs 5, 12 vs 13, and 14 vs 15) were identified. The structures of the new diterpenoids were elucidated using spectroscopic data analyses, electronic circular dichroism, and single-crystal X-ray diffraction data. The phytotoxic effects of compounds 120 on the growth of the roots and shoots of Poa annua and Festuca arundinacea seedlings were evaluated. Among the tested diterpenoids, 18 was the most active for inhibiting the growth of P. annua seedlings, and this compound was as active as glyphosate.