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Phytochemical Studies on Stemona Plants:  Isolation of Stemofoline Alkaloids

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journal contribution
posted on 2005-12-26, 00:00 authored by Thanapat Sastraruji, Araya Jatisatienr, Stephen G. Pyne, Alison T. Ung, Wilford Lie, Morwenna C. Williams
Six new stemofoline alkaloids, (2‘R)-hydroxystemofoline (5), (3‘R)-stemofolenol (6), (3‘S)-stemofolenol (7), 1‘,2‘-didehydrostemofoline-N-oxide (8), the first C19 stemofoline alkaloid, methylstemofoline (9), and the first glycosidated Stemona alkaloid, stemofolinoside (10), and three known alkaloids, (2‘S)-hydroxystemofoline (2), (11Z)-1‘,2‘-didehydrostemofoline (3), and (11E)-1‘,2‘-didehydrostemofoline (4), have been isolated from a root extract of an unidentified Stemona species. The structure and relative configuration of these new alkaloids have been determined by spectral data interpretation and from semisynthetic studies.