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Download filePhotothermal-Controlled Generation of Alkyl Radical from Organic Nanoparticles for Tumor Treatment
journal contribution
posted on 2019-01-21, 00:00 authored by Rui Xia, Xiaohua Zheng, Xiuli Hu, Shi Liu, Zhigang XieThe
therapeutic properties of light are well known for photodynamic
or photothermal therapy, which could cause irreversible photodamage
to tumor tissues. Although photodynamic therapy (PDT) has been proved
in the clinic, the efficacy is not satisfactory because of complicated
tumor microenvironments. For example, the hypoxia in solid tumor has
a negative effect on the generation of singlet oxygen. To address
the hypoxia issues in PDT, leveraging alkyl radical is an available
option due to the oxygen-independent feature. In this work, a new
kind of organic nanoparticles (tripolyphosphate (TPP)-NN NPs) from
porphyrin and radical initiator is developed. Under near-infrared
light irradiation, TPP-NN NPs will split and release alkyl radical,
which could induce obvious cytotoxicity both in normal and hypoxia
environment. The photothermal-controlled generation of alkyl radical
could significantly inhibit the growth of cervical cancer and show
ignorable systemic toxicity. This activatable radical therapy opens
up new possibilities for the application of PDT in hypoxia condition.
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photodynamic therapyrelease alkylPhotothermal-Controlled Generationnear-infrared light irradiationAlkyl RadicalTPP-NN NPstumor tissuesshow ignorablehypoxia issuesPDTphotothermal therapyTumor Treatmenthypoxia environmentOrganic Nanoparticlesphotothermal-controlled generationoxygen-independent featuresinglet oxygentumor microenvironmentshypoxia condition