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Photoredox/Cobalt-Catalyzed Phosphinyloxy Radical Addition/Cyclization Cascade: Synthesis of Phosphaisocoumarins

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posted on 2019-05-16, 00:00 authored by Ming-Ming Qiao, Yi-Yin Liu, Sheng Yao, Tian-Cong Ma, Zi-Long Tang, De-Qing Shi, Wen-Jing Xiao
A novel visible-light photoredox-catalyzed phosphinyloxy radical addition/cyclization cascade of arylphosphinic acids or arylphosphonic acid monoesters with alkynes has been developed, which provides an efficient and practical access to various phosphaisocoumarins by using a dual catalytic system containing an acridinium photosensitizer and a cobaloxime proton-reducing catalyst [Co­(dmgH)2]­PyCl at ambient temperature. This method has advantages of a broad substrate scope, mild condition, as well as no sacrificial oxidant.

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