posted on 2023-12-21, 16:06authored byAllie
W. Guerra, Joshua G. Pierce
We report a photoredox methodology for C(sp3)–C(sp3) coupling between α-bromoesters and
triethylamine capable
of accessing building blocks with handles for further functionalization.
Mechanistic studies indicate the presence of a carbon centered radical.
The achiral substrates obtained with this method have the potential
to be elaborated to access enantioenriched scaffolds with increased
molecular complexity.