posted on 2025-01-30, 08:13authored byChen Li, Shouyun Yu
We herein present a green and mild photoredox strategy
for constructing
a framework of benzannulated 6,5-spiroketal glycosides. This method
employs various O-arylacetylene glycosides and aryl
ketone acids as the starting materials, facilitating the rapid and
straightforward synthesis of 6,5-spiroketal glycosides with up to
92% yields under photoredox catalytic conditions. This efficient approach
has the potential to significantly enhance the molecular library of
carbohydrate-based pharmaceuticals.