posted on 2024-01-17, 17:33authored byBabasaheb
Sopan Gore, Chun-Cheng Chen, Ping-Yu Lin, Jeh-Jeng Wang
A dual nickel- and
iridium-photocatalyzed radical cascade bicyclization
reaction for the synthesis of highly complex molecular structures
in an atom- and step-economic manner has been described. A series
of radical precursors are utilized for the divergent synthesis of
diversely substituted fluorenes and indenoazepinones bearing quaternary
carbons by using cascade cyclization reactions of 1,5-enynes. This
reaction is characterized by its mild conditions, broad substrate
scope, excellent selectivity, and satisfactory yield including facile
scale-up synthesis.