posted on 2017-08-11, 00:00authored bySpencer
P. Pitre, Juan C. Scaiano, Tehshik P. Yoon
Indole
alkaloids represent an important class of molecules, with
many naturally occurring derivatives possessing significant biological
activity. One area that requires further development in the synthesis
of indole derivatives is the Diels–Alder reaction. In this
work, we expand on our previously developed heterogeneous protocol
for the [4 + 2] cycloaddition of indoles and electron-rich dienes
mediated by platinum nanoparticles supported on titanium dioxide semiconductor
particles (Pt(0.2%)@TiO2) with visible-light irradiation.
This reaction proceeds with broad scope and is more efficient per
incident photon than the previous homogeneous method, and the catalyst
can be easily recycled and reused.