Herein, we describe a photocatalytic method for the direct
incorporation
of an oxime functional group at inert C(sp3)–H bonds
of ethers, amides, alcohols, amines, and alkanes via HAT with photoexcited
eosin Y under mild conditions using air and a blue LED. Many useful
functional groups are tolerated in this process, and the reaction
is scalable. A series of mechanistic studies were carried out to support
the radical pathway proposed for the process.