American Chemical Society
ol2c03300_si_001.pdf (12.18 MB)

Photocatalytic Incorporation of an Oxime Ether Functional Group at Inert C(sp3)–H Bonds via HAT

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journal contribution
posted on 2022-10-26, 13:42 authored by Jayanta Dey, Subhasis Paul, Manotosh Bhakat, Joyram Guin
Herein, we describe a photocatalytic method for the direct incorporation of an oxime functional group at inert C(sp3)–H bonds of ethers, amides, alcohols, amines, and alkanes via HAT with photoexcited eosin Y under mild conditions using air and a blue LED. Many useful functional groups are tolerated in this process, and the reaction is scalable. A series of mechanistic studies were carried out to support the radical pathway proposed for the process.