nn5b06663_si_001.pdf (498.79 kB)
Download filePhoto-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration
journal contribution
posted on 2016-01-26, 00:00 authored by Dongquan Shi, Xingquan Xu, Yanqi Ye, Kai Song, Yixiang Cheng, Jin Di, Quanyin Hu, Jianxin Li, Huangxian Ju, Qing Jiang, Zhen GuThe regeneration of cartilage, an
aneural and avascular tissue,
is often compromised by its lack of innate abilities to mount a sufficient
healing response. Kartogenin (KGN), a small molecular compound, can
induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes.
The previous in vitro study showed that kartogenin
also had a chondrogenesis effect on synovium derived mesenchymal stem
cells (SMSCs). Herein, we present the effect of an ultraviolet-reactive,
rapidly cross-linkable scaffold integrated with kartogenin-loaded
nanoparticles using an innovational one-step technology. In
vivo studies showed its potential role for cell homing, especially
for recruiting the host’s endogenous cells, including BMSCs
and SMSCs, without cell transplantation. Of note, the regenerated
tissues were close to the natural hyaline cartilage based on the histological
tests, specific markers analysis, and biomechanical tests. This innovative
KGN release system makes the chondrogenesis efficient and persistent.