ol6b02885_si_001.pdf (3.58 MB)
Phosphine-Catalyzed Enantioselective [4 + 3] Annulation of Allenoates with C,N-Cyclic Azomethine Imines: Synthesis of Quinazoline-Based Tricyclic Heterocycles
journal contribution
posted on 2016-10-21, 13:14 authored by Chunhao Yuan, Leijie Zhou, Miaoren Xia, Zhanhu Sun, Dongqi Wang, Hongchao GuoWith
the use of a commercially available chiral phosphine as the
catalyst, the first catalytic enantioselective [4 + 3] annulation
of allenoates with C,N-cyclic azomethine imines is developed. The
reaction works efficiently under mild reaction conditions to afford
seven-membered ring-fused quinazoline-based tricyclic heterocycles
in high yields with good to excellent diastereo- and enantioselectivities.
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AllenoateEnantioselectivechiral phosphineseven-membered ring-fused quinazoline-based tricyclic heterocyclesAnnulationreaction conditionsallenoatediastereoannulationimineAzomethineSynthesiQuinazoline-Based Tricyclic HeterocyclesenantioselectiveIminecatalystazomethineyieldreaction worksPhosphine-Catalyzedenantioselectivitie
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