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Phosphine-Catalyzed Cascade Michael Addition/[4+2] Cycloaddition Reaction of Allenoates and 2‑Arylidene-1,3-indanediones

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journal contribution
posted on 18.03.2020, 19:44 by Wangyu Shi, Biming Mao, Jiaqing Xu, Qijun Wang, Wei Wang, Yongjun Wu, Xuefeng Li, Hongchao Guo
The phosphine-catalyzed cascade Michael addition/[4+2] cycloaddition reaction of tetrahydrobenzofuranone-derived allenoates and 2-arylidene-1,3-indanediones has been reported, affording spirocyclic 1,3-indanedione derivatives in moderate to high yields with moderate to good diastereoselectivities. A scaled-up reaction worked well under mild conditions, and a plausible mechanism is proposed.