Phenylboronic Acid Templated Gold Nanoclusters for Mucin Detection Using a Smartphone-Based Device and Targeted Cancer Cell Theranostics
journal contributionposted on 04.12.2017, 00:00 by Deepanjalee Dutta, Sunil Kumar Sailapu, Arun Chattopadhyay, Siddhartha Sankar Ghosh
A phenylboronic acid templated gold nanocluster probe was developed to detect biomarker mucin by a noninvasive fluorescence-based method using a point-of-care smartphone-based fluorescence detection device. The gold nanocluster probe is able to detect mucin specifically. The same probe was applied for in vitro targeted bioimaging of HeLa and Hep G2 cancer cells, and it demonstrated specific therapeutic effects toward cancer cells as well as multicellular tumor spheroids imparting theranostic properties. The module is found to be more effective toward HeLa cells, and a pathway of cell death was established using flow-cytometry-based assays.
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noninvasive fluorescence-based methodcancer cellsSmartphone-Based Devicebiomarker mucinTemplated Gold NanoclustersTargeted Cancer Cell Theranosticsgold nanocluster probecell deaththeranostic propertiesflow-cytometry-based assaysHep G 2 cancer cellsmulticellular tumor spheroidspoint-of-care smartphone-based fluorescence detection deviceMucin DetectionHeLa cellsphenylboronic acid templated gold nanocluster probe