American Chemical Society
ol5035518_si_001.pdf (2.82 MB)

PhenoFluorMix: Practical Chemoselective Deoxyfluorination of Phenols

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journal contribution
posted on 2015-02-06, 00:00 authored by Teppei Fujimoto, Tobias Ritter
A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N′-1,3-bis­(2,6-diisopropylphenyl)­chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in air. In this paper, we demonstrate the practicality of the reagent and exhibit the deoxyfluorination of a variety of phenols and heterocycles.