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Phenanthroline‑tBuOK Promoted Intramolecular C–H Arylation of Indoles with ArI under Transition-Metal-Free Conditions
journal contribution
posted on 2018-12-06, 13:19 authored by Xiang-Huan Shan, Bo Yang, Hong-Xing Zheng, Jian-Ping Qu, Yan-Biao KangThe
first example of phenanthroline-tBuOK
promoted intramolecular radical C–H arylation of N-(2-iodobenzyl)indoles without involvement of transition
metals has been developed. A variety of substituted 6H-isoindolo [2, 1-a] indoles were prepared by a simple and efficient
intramolecular cyclization using 1,10-phenanthroline in the presence
of potassium tert-butoxide and chlorobenzene. This
strategy provides a fast and versatile access to isoindolo[2,1-a]indole derivatives for the synthesis of pharmaceuticals
and organic electroluminescent (EL) materials.
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Indolepotassium tertphenanthrolinechlorobenzenetransition metalsindoleArylationvarietyisoindoloaccessstrategyelectroluminescentderivativesynthesisELarylationpharmaceuticalTransition-Metal-Free Conditionspresencematerial6 Ht BuOKPromotedArIintramolecular cyclizationPhenanthrolinebutoxideiodobenzylIntramolecularinvolvement1-
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