Phainanolide A, Highly Modified and Oxygenated Triterpenoid from Phyllanthus hainanensis
journal contributionposted on 23.08.2017, 13:35 authored by Yao-Yue Fan, Li-She Gan, Hong-Chun Liu, Heng Li, Cheng-Hui Xu, Jian-Ping Zuo, Jian Ding, Jian-Min Yue
Phainanolide A (1), a highly modified triterpenoid incorporating an unprecedented 6/9/6 heterotricyclic system and a highly oxygenated 5,5-spirocyclic ketal lactone, along with three new triterpenoids 2–4 were isolated from Phyllanthus hainanensis. Their structures were completely elucidated by a combination of diverse methods including 2D NMR, quantum chemical NMR and ECD calculations, and NMR data analogy with model compounds. Compounds 1–4 exhibited both remarkable cytotoxic and immunosuppressive activities.