American Chemical Society
ol7b02181_si_001.pdf (4.26 MB)

Phainanolide A, Highly Modified and Oxygenated Triterpenoid from Phyllanthus hainanensis

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journal contribution
posted on 2017-08-23, 13:35 authored by Yao-Yue Fan, Li-She Gan, Hong-Chun Liu, Heng Li, Cheng-Hui Xu, Jian-Ping Zuo, Jian Ding, Jian-Min Yue
Phainanolide A (1), a highly modified triterpenoid incorporating an unprecedented 6/9/6 heterotricyclic system and a highly oxygenated 5,5-spirocyclic ketal lactone, along with three new triterpenoids 24 were isolated from Phyllanthus hainanensis. Their structures were completely elucidated by a combination of diverse methods including 2D NMR, quantum chemical NMR and ECD calculations, and NMR data analogy with model compounds. Compounds 14 exhibited both remarkable cytotoxic and immunosuppressive activities.