posted on 2022-02-07, 15:04authored byZhuqing Liu, Shaobin Sun, Jiang Lou
An efficient PhIO-mediated oxidative
CC bond cleavage and
reassembly of enaminone toward oxazolone with high regioselectivity
has been reported. DFT calculations revealed that the reaction proceeded
through an oxygen atom transfer, CC bond cleavage, alkylthio
migration, and reassembly cascade. This strategy is highlighted by
high atom and step economy with formation of five bonds in one pot
and generation of a high-valued oxazolone skeleton under mild conditions.