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Perfluorooctane Sulfonate Plasma Half-Life Determination and Long-Term Tissue Distribution in Beef Cattle (Bos taurus)
journal contribution
posted on 2015-12-30, 00:00 authored by Sara J. Lupton, Kerry L. Dearfield, John J. Johnston, Sarah Wagner, Janice
K. HuwePerfluorooctane
sulfonate (PFOS) is used in consumer products as
a surfactant and is found in industrial and consumer waste, which
ends up in wastewater treatment plants (WWTPs). PFOS does not breakdown
during WWTP processes and accumulates in the biosolids. Common practices
include application of biosolids to pastures and croplands used for
feed, and as a result, animals such as beef cattle are exposed to
PFOS. To determine plasma and tissue depletion kinetics in cattle,
2 steers and 4 heifers were dosed with PFOS at 0.098 mg/kg body weight
and 9.1 mg/kg, respectively. Plasma depletion half-lives for steers
and heifers were 120 ± 4.1 and 106 ± 23.1 days, respectively.
Specific tissue depletion half-lives ranged from 36 to 385 days for
intraperitoneal fat, back fat, muscle, liver, bone, and kidney. These
data indicate that PFOS in beef cattle has a sufficiently long depletion
half-life to permit accumulation in edible tissues.