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Peptide Nucleic Acids with a Flexible Secondary Amine in the Backbone Maintain Oligonucleotide Binding Affinity

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journal contribution
posted on 09.12.2004, 00:00 by Michael C. Myers, Jonathan K. Pokorski, Daniel H. Appella
Replacing a secondary amide in a peptide nucleic acid backbone with a more flexible secondary amine affords an oligomer that surprisingly maintains the same binding affinity to complementary oligonucleotides as the unmodified polyamide oligomer.

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