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Peptide Hydrogels Assembled from Enzyme-Adsorbed Mesoporous Silica Nanostructures for Thermoresponsive Doxorubicin Release

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posted on 2022-01-03, 19:34 authored by Bing Li, Miryam Criado-Gonzalez, Alexandre Adam, Joëlle Bizeau, Christophe Mélart, Alain Carvalho, Sylvie Bégin, Dominique Bégin, Loïc Jierry, Damien Mertz
The development of nanocomposite supramolecular hydrogels, which can be activated by local or external stimuli (pH, redox, enzyme, heat), is highly promising for various applications including implantable materials for antitumor or tissue engineering applications. Here, we show that large pore stellate mesoporous silica modified with isobutyramide grafts allow >100% wt. loading of enzymes, which ensures through the enzyme-assisted self-assembly an easy, rapid, and efficient way to design smart thermoresponsive nanocomposite supramolecular hydrogels. The typical temperature increase (42 °C), which may be induced by hyperthermia anticancer treatments, leads to the controlled-release of doxorubicin encapsulated in the resulting peptide self-assembled material.

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