American Chemical Society
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Peptide Amphiphiles with Distinct Supramolecular Nanostructures for Controlled Antibacterial Activities

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journal contribution
posted on 2018-05-30, 00:00 authored by Ruilian Qi, Pengbo Zhang, Jian Liu, Lingyun Zhou, Chengcheng Zhou, Na Zhang, Yuchun Han, Shu Wang, Yilin Wang
Gemini-type peptide amphiphiles 12-(Lys)n-12 (n = 2, 4, 6) with different lysine spacer lengths have been established and exhibit excellent antibacterial activities. By varying the lysine number in the spacer, the distinct aggregates with zero- to three-dimensional structures (fibers, short rods, and spherical aggregates) are formed. These different length/diameter ratios of aggregates have great effects on the antibacterial activities and cytotoxicity. 12-(Lys)2-12 has a relatively higher minimal inhibitory concentration (MIC) value and shows toxicity toward mammalian cells just above its MIC value, while 12-(Lys)4-12 and 12-(Lys)6-12 have lower MIC values and no cytotoxicity even at 5 times the MIC values.