Pd(OAc)₂-Catalyzed Fluoride-Free Cross-Coupling Reactions of Arylsiloxanes with Aryl Bromides in Aqueous Medium

Mild conditions have been developed to achieve the Pd(OAc)₂-catalyzed fluoride-free cross-coupling between the aryl bromides and arylsiloxanes in good to high yields in aqueous medium. The success of the reactions requires the presence of poly(ethylene glycol) (PEG) and 3 equiv of sodium hydroxide. The product was easily separated with ethyl ether extraction, and the catalytic system can be reused eight times with high efficiency.