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Pd(II)-Catalyzed One-Pot, Three-Step Route for the Synthesis of Unsymmetrical Acridines

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journal contribution
posted on 01.11.2013, 00:00 by Hai-Ming Guo, Run-Ze Mao, Qiao-Tian Wang, Hong-Ying Niu, Ming-Sheng Xie, Gui-Rong Qu
Unsymmetric acridines are synthesized via a one-pot amination/cyclization/aromatization reaction for the first time. With Pd(OAc)2-X-Phos as the catalyst, a series of unsymmetric acridines are obtained in moderate to excellent yields (up to 99% yield). Meanwhile, the diphenylamine intermediate could be isolated, which is evidence of the domino process.