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Pd(II)-Catalyzed Cycloisomerization/Dipolar Cycloaddition Cascade of N‑Arylnitrone Alkynes with Olefins

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journal contribution
posted on 07.08.2015, 00:00 by Yu-Liu Du, Yi-Fan Zhu, Zhi-Yong Han
A cycloisomerization/dipolar cycloaddition tandem reaction of nitrone alkynes and electron-deficient olefins was described by employing a simple palladium catalyst. N-Arylnitrone alkynes, which were not well tolerated in previously reported methodologies, were successfully incorporated in the tandem reaction with generally good yields and moderate diastereoselectivities.