American Chemical Society
ja8b03509_si_001.pdf (18.35 MB)

Pd(II)-Catalyzed Enantioselective C(sp3)–H Arylation of Free Carboxylic Acids

Download (18.35 MB)
journal contribution
posted on 2018-05-09, 00:00 authored by Peng-Xiang Shen, Liang Hu, Qian Shao, Kai Hong, Jin-Quan Yu
A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C­(sp3)–H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.