posted on 2018-05-09, 00:00authored byPeng-Xiang Shen, Liang Hu, Qian Shao, Kai Hong, Jin-Quan Yu
A monoprotected
aminoethyl amine chiral ligand based on an ethylenediamine
backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)–H arylation of cyclopropanecarboxylic and 2-aminoisobutyric
acids without using exogenous directing groups. This new chiral catalyst
affords new disconnection for preparing diverse chiral carboxylic
acids from simple starting materials that are complementary to the
various ring forming approaches.