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Pd-Catalyzed Tandem sp2–sp3 Coupling Reactions of Chiral Stannolanes: An Efficient Preparation of Optically Active Tetrahydrobenz[f]isoindoles

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journal contribution
posted on 19.02.2016, 17:52 by Akio Kamimura, Masahiro So, Shingo Ishikawa, Hidemitsu Uno
A novel double Migita–Kosugi–Stille coupling reaction with dihydrostannolanes, which are readily available from a radical cascade reaction, was achieved with dihalobenzenes in the presence of a palladium catalyst. Use of unsymmetrical 1-bromo-2-iodobenzene derivatives accomplished the double coupling reaction which gave tetrahydrobenz[f]isoindoles in a regioselective manner.

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