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Pd-Catalyzed Regioselective Allylation of Mono- and Disubstituted Hydrazines

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journal contribution
posted on 05.07.2013, 00:00 by Svetlana Tšupova, Uno Mäeorg
Palladium-catalyzed allylation of hydrazines using allyl alcohols is reported. This highly efficient protocol furnishes monoallylated hydrazines selectively, in 27–99% yields. Following an optimization of the reaction conditions and of the Pd-ligands, the allylations of both mono- and disubstituted hydrazines were investigated, as well as the effects of C2-substitution on the allylating agent. Of particular interest, a novel method for the selective monoallylation of monosubstituted hydrazines is demonstrated.