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Pd-Catalyzed Oxidative ortho-C–H Borylation of Arenes

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journal contribution
posted on 11.01.2012, 00:00 by Hui-Xiong Dai, Jin-Quan Yu
The development of a Pd-catalyzed oxidative ortho-C–H borylation with N-arylbenzamides is reported. A modified dibenzylideneacetone (dba) ligand, a weak base, and a strong oxidant are critical for obtaining good yields. The reaction is tolerant of electron-deficient and electron-rich benzamides derived from readily available benzoic acids. The borylated products can be converted to various synthons via diverse transformations.