Pd-Catalyzed
Enantioselective C–H Iodination:
Asymmetric Synthesis of Chiral Diarylmethylamines

Chu, Ling; Wang, Xiao-Chen; Moore, Curtis
E.; Rheingold, Arnold L.; Yu, Jin-Quan

doi:10.1021/ja408864c.s001

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Pd-Catalyzed Enantioselective C–H Iodination: Asymmetric Synthesis of Chiral Diarylmethylamines

journal contribution

posted on 2013-11-06, 00:00 authored by Ling Chu, Xiao-Chen Wang, Curtis E. Moore, Arnold L. Rheingold, Jin-Quan Yu

An enantioselective C–H iodination reaction using a mono-N-benzoyl-protected amino acid has been developed for the synthesis of chiral diarylmethylamines. The reaction uses iodine as the sole oxidant and proceeds at ambient temperature and under air.