Pd-Catalyzed Decarboxylative Arylation of Thiazole, Benzoxazole, and Polyfluorobenzene with Substituted Benzoic Acids
journal contributionposted on 02.04.2010, 00:00 by Kai Xie, Zhiyong Yang, Xingjian Zhou, Xiujian Li, Sizhuo Wang, Ze Tan, Xiangyu An, Can-Cheng Guo
A Pd-catalyzed decarboxylative coupling of thiazoles and benzoxazole with various substituted benzoic acids is developed. The reaction is compatible with both electron-rich and electron-poor benzoic acids. It can also be extended to the synthesis of polyfluoro-substituted biaryls using polyfluorobenzenes as the starting materials.