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Pd-Catalyzed Decarboxylative Arylation of Thiazole, Benzoxazole, and Polyfluorobenzene with Substituted Benzoic Acids

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journal contribution
posted on 02.04.2010, 00:00 by Kai Xie, Zhiyong Yang, Xingjian Zhou, Xiujian Li, Sizhuo Wang, Ze Tan, Xiangyu An, Can-Cheng Guo
A Pd-catalyzed decarboxylative coupling of thiazoles and benzoxazole with various substituted benzoic acids is developed. The reaction is compatible with both electron-rich and electron-poor benzoic acids. It can also be extended to the synthesis of polyfluoro-substituted biaryls using polyfluorobenzenes as the starting materials.