Pd-Catalyzed Carboetherification of β,γ-Unsaturated Oximes: A Novel Approach to Δ²-Isoxazolines

A novel route to the synthesis of Δ²-isoxazoline derivatives is described. Reaction of β,γ-unsaturated oximes with aryl bromides via palladium-catalyzed carboetherification affords 3,5-disubstituted Δ²-isoxazolines in good yields. The use of Xantphos as ligand is crucial for the transformation. The carboetherification products can be further converted to β-hydroxy ketones in the presence of Fe powder and NH₄Cl.