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Pd-Catalyzed Site-Selective C(sp2)–H Olefination and Alkynylation of Phenylalanine Residues in Peptides

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journal contribution
posted on 18.04.2019, 12:04 authored by Yong Zheng, Weibin Song
Pd-catalyzed site-selective C­(sp2)–H olefination and alkynylation of phenylalanine residues in peptides are described. The amino acids within the peptides are used as native bidentate directing groups to facilitate C–H functionalization. This protocol would provide appealing strategies for the postsynthetic modification of peptides.