Pd-Catalyzed Sequential
Formation of C–C Bonds:
A New Strategy for the Synthesis of (E)‑α,β-Unsaturated
Carbonyl Compounds from Sulfoxonium Ylides and 1‑Iodo-2-((2-methylallyl)oxy)benzene
Compounds
α,β-Unsaturated carbonyl
compounds are significant
moieties in many biological molecules and have attracted considerable
attention in organic synthetic chemistry. A Pd-catalyzed cascade cyclization
for the synthesis of (E)-α,β-unsaturated
carbonyl compounds with the sequential formation of C–C bonds
was developed. This method offers high efficiency, good functional
group tolerance, and moderate to excellent yields and generally displays
high stereoselectivity.