jo2c00781_si_001.pdf (8.37 MB)
Pd-Catalyzed Regioselective Intramolecular Allylic C–H Amination of 1,1-Disubstituted Alkenyl Amines
journal contribution
posted on 2022-05-13, 19:13 authored by Young
Ho Kim, Dong Bin Kim, Su San Jang, So Won YounPd-Catalyzed
intramolecular allylic C–H amination of 1,1-disubstituted
alkenyl amines with various allylic tethers (X = O, NMs, CH2) was developed. This process allows for the divergent synthesis
of 1,3-X,N-heterocycles through
a regioselective allylic C–H cleavage and π-allylpalladium
formation. Particularly noteworthy is the use of substrates containing
a labile allylic moiety and new simple catalytic systems capable of
promoting highly chemo- and regioselective allylic C–H amination
by overcoming significant challenges.