American Chemical Society
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Pd-Catalyzed Regioselective Intramolecular Allylic C–H Amination of 1,1-Disubstituted Alkenyl Amines

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Version 2 2022-05-13, 19:13
Version 1 2022-05-12, 14:09
journal contribution
posted on 2022-05-13, 19:13 authored by Young Ho Kim, Dong Bin Kim, Su San Jang, So Won Youn
Pd-Catalyzed intramolecular allylic C–H amination of 1,1-disubstituted alkenyl amines with various allylic tethers (X = O, NMs, CH2) was developed. This process allows for the divergent synthesis of 1,3-X,N-heterocycles through a regioselective allylic C–H cleavage and π-allylpalladium formation. Particularly noteworthy is the use of substrates containing a labile allylic moiety and new simple catalytic systems capable of promoting highly chemo- and regioselective allylic C–H amination by overcoming significant challenges.