jo6b01103_si_001.pdf (2.93 MB)
Pd-Catalyzed Ligand-Free Synthesis of Arylated Heteroaromatics by Coupling of N‑Heteroaromatic Bromides with Iodobenzene Diacetate, Iodosobenzene, or Diphenyliodonium Salts
journal contribution
posted on 2016-07-26, 00:00 authored by Xiajun Wang, Yongqin He, Mengdan Ren, Shengkang Liu, He Liu, Guosheng HuangAn
efficient method for synthesizing arylated heteroaromatics has
been reported via Pd-catalyzed ligand-free cross-coupling of N-heteroaromatic bromides with iodine(III) reagents under
mild conditions. Iodobenzene diacetate, iodosobenzene, and diphenyliodonium
salts act as ideal arylated sources in this reaction, producing bioactive
aromatic-substituted pyridines and quinolines in moderate to high
yields.