Pd-Catalyzed Enantioselective Dicarbofunctionalization
of Alkene to Access Disubstituted Dihydroisoquinolinone

Chen, Qiaoyu; Li, Sanliang; Xie, Xiaoxiao; Guo, Hao; Yang, Junfeng; Zhang, Junliang

doi:10.1021/acs.orglett.1c00974.s001

Pd-Catalyzed Enantioselective Dicarbofunctionalization of Alkene to Access Disubstituted Dihydroisoquinolinone

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posted on 2021-05-13, 15:40 authored by Qiaoyu Chen, Sanliang Li, Xiaoxiao Xie, Hao Guo, Junfeng Yang, Junliang Zhang

A Pd/Xu-Phos-catalyzed asymmetric Heck/Suzuki domino reaction has been developed that shows high functional group tolerance and enables coupling with various aryl/alkenyl borates. A series of chiral disubstituted dihydroisoquinolinones could be obtained in good yields and excellent enantioselectivities.

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Keywords

domino Pd-Catalyzed Enantioselective Dicar...yield Alkene series Access Disubstituted Dihydroisoquin...Heck borates group tolerance aryl chiral disubstituted dihydroisoquin...enantioselectivitie

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Pd-Catalyzed Enantioselective Dicarbofunctionalization of Alkene to Access Disubstituted Dihydroisoquinolinone

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