Pd-Catalyzed Direct ortho-C–H
Arylation of Aromatic Ketones Enabled by a Transient Directing Group

Xu, Jiancong; Liu, Yang; Wang, Ying; Li, Yajuan; Xu, Xiaohua; Jin, Zhong

doi:10.1021/acs.orglett.7b00363.s001

ol7b00363_si_001.pdf (7.9 MB)

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Pd-Catalyzed Direct ortho-C–H Arylation of Aromatic Ketones Enabled by a Transient Directing Group

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posted on 2017-03-24, 12:53 authored by Jiancong Xu, Yang Liu, Ying Wang, Yajuan Li, Xiaohua Xu, Zhong Jin

The Pd-catalyzed direct C(sp²)–H arylation of aromatic ketones using a transient directing group is described. The ketimine/carboxylate bidentate directing group in situ generated from aromatic ketone and glycine enabled a palladium-catalyzed ortho-C–H arylation, which shows extensive substrate compatibility.

Pd-Catalyzed Direct ortho-C–H Arylation of Aromatic Ketones Enabled by a Transient Directing Group

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