ol7b00363_si_001.pdf (7.9 MB)
Pd-Catalyzed Direct ortho-C–H Arylation of Aromatic Ketones Enabled by a Transient Directing Group
journal contributionposted on 2017-03-24, 12:53 authored by Jiancong Xu, Yang Liu, Ying Wang, Yajuan Li, Xiaohua Xu, Zhong Jin
The Pd-catalyzed direct C(sp2)–H arylation of aromatic ketones using a transient directing group is described. The ketimine/carboxylate bidentate directing group in situ generated from aromatic ketone and glycine enabled a palladium-catalyzed ortho-C–H arylation, which shows extensive substrate compatibility.