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Download filePd-Catalyzed Direct ortho-C–H Arylation of Aromatic Ketones Enabled by a Transient Directing Group
journal contribution
posted on 2017-03-24, 12:53 authored by Jiancong Xu, Yang Liu, Ying Wang, Yajuan Li, Xiaohua Xu, Zhong JinThe Pd-catalyzed
direct C(sp2)–H
arylation of aromatic ketones using a transient directing group is
described. The ketimine/carboxylate bidentate directing group in situ
generated from aromatic ketone and glycine enabled a palladium-catalyzed ortho-C–H arylation, which shows extensive substrate
compatibility.