posted on 2020-10-15, 22:03authored byLinlin Shi, Yingdong He, Jianxian Gong, Zhen Yang
An efficient palladium-catalyzed
decarboxylative cycloaddition
process of vinyl cyclic carbonates and vinyloxazolidinones for the
synthesis of highly substituted δ-lactone and δ-lactam
derivatives was developed. This protocol exhibits several unique characteristics,
including broad substrate scope, good functional group tolerance,
and operational convenience, which enables a regioselective access
to a variety of lactone and lactam scaffolds in moderate to good yield.
The redox-neutral catalytic system promotes formation of substituted
scaffolds with in situ generation of a cyclic tetra-substituted double
bond functionality.