American Chemical Society
om0c00646_si_001.pdf (9.62 MB)

Pd-Catalyzed Decarboxylative Cycloaddition for the Synthesis of Highly Substituted δ‑Lactones and Lactams

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journal contribution
posted on 2020-10-15, 22:03 authored by Linlin Shi, Yingdong He, Jianxian Gong, Zhen Yang
An efficient palladium-catalyzed decarboxylative cycloaddition process of vinyl cyclic carbonates and vinyloxazolidinones for the synthesis of highly substituted δ-lactone and δ-lactam derivatives was developed. This protocol exhibits several unique characteristics, including broad substrate scope, good functional group tolerance, and operational convenience, which enables a regioselective access to a variety of lactone and lactam scaffolds in moderate to good yield. The redox-neutral catalytic system promotes formation of substituted scaffolds with in situ generation of a cyclic tetra-substituted double bond functionality.