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Pd-Catalyzed Decarbonylative Cross-Couplings of Aroyl Chlorides

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journal contribution
posted on 19.07.2017, 20:29 by Christian A. Malapit, Naoko Ichiishi, Melanie S. Sanford
This report describes a method for Pd-catalyzed decarbonylative cross-coupling that enables the conversion of carboxylic acid derivatives to biaryls, aryl amines, aryl ethers, aryl sulfides, aryl boronate esters, and trifluoromethylated arenes. The success of this transformation leverages the Pd0/Brettphos-catalyzed decarbonylative chlorination of aroyl chlorides, which can then participate in diverse cross-coupling reactions in situ using the same Pd catalyst.