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Pd-Catalyzed Coupling of γ‑C(sp3)–H Bonds of Oxalyl Amide-Protected Amino Acids with Heteroaryl and Aryl Iodides

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posted on 2016-06-10, 00:00 authored by Jian Han, Yongxiang Zheng, Chao Wang, Yan Zhu, Zhi-Bin Huang, Da-Qing Shi, Runsheng Zeng, Yingsheng Zhao
Pd-catalyzed regioselective coupling of γ-C­(sp3)–H bonds of oxalyl amide-protected amino acids with heteroaryl and aryl iodides is reported. A wide variety of iodides are tolerated, giving the corresponding products in moderate to good yields. Various oxalyl amide-protected amino acids were compatible in this C–H transformation, thus representing a practical method for constructing non-natural amino acid derivatives.

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