posted on 2016-06-10, 00:00authored byJian Han, Yongxiang Zheng, Chao Wang, Yan Zhu, Zhi-Bin Huang, Da-Qing Shi, Runsheng Zeng, Yingsheng Zhao
Pd-catalyzed regioselective
coupling of γ-C(sp3)–H bonds of oxalyl amide-protected
amino acids with heteroaryl
and aryl iodides is reported. A wide variety of iodides are tolerated,
giving the corresponding products in moderate to good yields. Various
oxalyl amide-protected amino acids were compatible in this C–H
transformation, thus representing a practical method for constructing
non-natural amino acid derivatives.