Pd-Catalyzed Alkene Diamination Reactions of Nitrogen Electrophiles: Synthesis of Cyclic Guanidines and Ureas Bearing Dialkylaminomethyl Groups
journal contributionposted on 2018-06-06, 15:25 authored by Luke J. Peterson, Janelle K. Kirsch, John P. Wolfe
The Pd-catalyzed coupling of N-allylguanidines or N-allylureas with O-benzoylhydroxylamine derivatives affords cyclic guanidines or cyclic ureas bearing dialkylaminomethyl groups. The desired products are obtained in good yield, and substrates bearing substituents at the allylic position are transformed with moderate diastereoselectivity. The mechanism of these reactions appears to involve anti-aminopalladation of the alkene, followed by a rare sp3C–sp3N bond-forming reductive elimination from an alkylpalladium complex that contains β-hydrogen atoms.
Pd-Catalyzed Alkene Diamination Reactionsbenzoylhydroxylamine derivativesCyclic GuanidinesalkeneallylguanidinePd-catalyzeddialkylaminomethyl groupsmechanismdiastereoselectivitycyclic ureasreductiveβ- hydrogen atomsSynthesialkylpalladiumaminopalladationbond-formingeliminationsubstituentallylureasubstratecyclic guanidinesspUreas Bearing Dialkylaminomethyl Groupsallylic positionNitrogen Electrophiles