posted on 2024-02-23, 13:03authored byMengmeng Sun, Jingtao Bi, Yingying Zhao, Junbo Gong
In the pharmaceutical industry, the production process
of most
active pharmaceutical ingredients involves at least one crystallization
step. Design of drug spheres via various spherical crystallization
technologies can impart crystals with certain superior attributes
including high flowability and compressibility as well as excellent
mechanical properties. Some new spherical crystallization approaches
and design principles have been proposed in recent years. This review
aims to review the up-to-date design principles and preparation technologies
of drug spheres, providing a guide for design, preparation, and performance
evaluation of the drug spheres. Herein, we review the mechanisms and
design principles of the spherical crystallization first, and subsequently
various technologies reported in the literature are reviewed with
the critical process parameters being analyzed. Lastly, the challenges
facing the development of spherical crystallization for drugs are
discussed.