American Chemical Society
np2000705_si_001.pdf (1.18 MB)

Paraminabeolides A−F, Cytotoxic and Anti-inflammatory Marine Withanolides from the Soft Coral Paraminabea acronocephala

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journal contribution
posted on 2011-05-27, 00:00 authored by Chih-Hua Chao, Kuei-Ju Chou, Zhi-Hong Wen, Guey-Horng Wang, Yang-Chang Wu, Chang-Feng Dai, Jyh-Horng Sheu
Six new withanolides, paraminabeolides A−F (16), along with five known compounds, minabeolides-1, -2, -4, -5, and -8 (711), were isolated from a Formosan soft coral, Paraminabea acronocephala. The structures of these compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The absolute configuration of 4 was determined by the application of Mosher’s method. Compounds 1 and 7 were cytotoxic toward Hep G2 cancer cells. Compounds 14 and 710 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein. Compounds 710 also could effectively reduce the expression of COX-2 protein.