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Palladium/Norbornene-Catalyzed Ortho-Acylation and Ipso-Selenation via C(O)–Se Bond Cleavage: Synthesis of α‑Carbonyl Selane

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journal contribution
posted on 01.02.2018, 22:30 by Xiaozhong Fan, Zhenhua Gu
A palladium/norbornene-catalyzed synthetic method that combines selective ortho C–H bond activation with sequential reactions to form complex selenide compounds has been developed. The C­(O)–Se bond in selenoates is successfully cleaved, and various kinds of α-carbonyl selanes were synthesized in decent to excellent yields. The reaction has good functional group tolerance and broad substrate scope.

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