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Palladium(II)-Catalyzed Direct Intermolecular Alkenylation of Chromones

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journal contribution
posted on 19.08.2011, 00:00 by Donghee Kim, Sungwoo Hong
A new efficient method for the direct alkenylation of chromones via a palladium(II)-catalyzed C–H functionalization reaction was developed. The use of pivalic acid with Cu(OAc)3/Ag2CO3 provided superior reactivity in the cross-coupling of chromones with alkene partners. This approach represents a significant advance over the existing two-step method and afforded various 3-vinylchromone derivatives, which are privileged structures in many biologically active compounds and versatile synthetic building blocks.