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Download filePalladium(II)-Catalyzed Cascade Reactions of Ene–Ynes Tethered to Cyano/Aldehyde: Access to Naphtho[1,2‑b]furans and Benzo[g]indoles
journal contribution
posted on 2019-06-26, 17:46 authored by Moumita Jash, Sukanya De, Subhendu Pramanik, Chinmay ChowdhuryAn efficient palladium(II)-catalyzed
cascade reaction of ene–yne
substrates carrying cyano/aldehyde group is described. It involves
successive hetero- and benz-annulations in one pot via trans-oxo/aminopalladation onto alkyne, followed by 1,2-addition to cyano/aldehyde,
providing a convenient synthesis of both naphtho[1,2-b]furans and benzo[g]indoles. The reaction constitutes
a fast intramolecular assembly through several carbon–carbon
and carbon–heteroatom bond formations taking place in one pot.
The reactions are operationally simple, compatible with a range of
functional groups and atom-economical in nature.