American Chemical Society
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Palladium(III)-Catalyzed Fluorination of Arylboronic Acid Derivatives

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journal contribution
posted on 2013-09-25, 00:00 authored by Anthony R. Mazzotti, Michael G. Campbell, Pingping Tang, Jennifer M. Murphy, Tobias Ritter
A practical, palladium-catalyzed synthesis of aryl fluorides from arylboronic acid derivatives is presented. The reaction is operationally simple and amenable to multigram-scale synthesis. Evaluation of the reaction mechanism suggests a single-electron-transfer pathway, involving a Pd­(III) intermediate that has been isolated and characterized.